25+ How Long Should I Cook A 2 Pound Meatloaf At 375 Degrees Background. For a great loaf, get to know chuck. However, meatloaf can take a really long time to cook under standard baking temperatures like 350 degrees fahrenheit, making it not ideal for hasty situations.
Cut into thick slices and serve.
<ul><li>remember, to answer the question, how long do i cook a two pound meatloaf, you have to know two things: Ground beef should reach a temperature of 165 degrees fahrenheit. So, pay attention to how long you let the cooked meat sit before serving. If chicken is a regular item on your menu, baked chicken breast is a simple.